주요 발표 논문
Major Publications
Site-specific Protein Modification
Science, 354(6312):623-626. (2016)
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Publications
2023
1. Marcel Janis Beha, Joo-Chan Kim, San Hae Im, Yunsu Kim, Seungju Yang, Juhee Lee, Yu Ri Nam, Haeshin Lee, Hee-Sung Park, and Hyun Jung Chung
Advanced Science Jul 2023; Recently Published
Bioorthogonal CRISPR/Cas9-Drug Conjugate: A Combinatorial Nanomedicine Platform
2022
1. Deokhee Kang, Do-wook Kim, Joo-Chan Kim, and Hee-Sung Park
Angew. Chem. Intl. Ed. Dec 2022; 62(7):e202214815
A Versatile Strategy for Screening Custom-Designed Warhead-Armed Cyclic Peptide Inhibitors
2. Prasad M.Sonawanea, Woohyun Lee, Yunsu Kim, Arkaprava Roychaudhury, Vikas K.Bhosalea, Donghyeon Kim, Hee-Sung Park, Cheol-Hee Kim, and David G.Churchill
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Feb 2022; 267(2):120568.
Phosphinate–benzoindocyanin fluorescent probe for endogenous mitochondrial peroxynitrite detection in living cells and gallbladder access in inflammatory zebrafish animal models.
2021
1. Prasad M. Sonawane, Tesla Yudhistira, Mahesh B. Halle, Arkaprava Roychaudhury, Yunsu Kim, Sachin S. Surwase, Vikas K. Bhosale, Juhyeon Kim, Hee-Sung Park, Yeu-chun Kim, Cheol-Hee Kim, and David G. Churchill
Dyes and Pigments. July 2021; 191:109371.
A water-soluble boronate masked benzoindocyanin fluorescent probe for the detection of endogenous mitochondrial peroxynitrite in live cells and zebrafish as inflammation models.
DOI: 10.1016/j.dyepig.2021.109371
2020
1. Donghyeok Gang, and Hee-Sung Park
ChemBioChem, 22(3):460-468.
Noncanonical Amino Acids in Synthetic Biosafety and Post-translational Modification Studies
DOI: 10.1002/cbic.202000437
2. Phuong Thi Mai Duong, Anh Thi Ngoc Bui, Seong-Ok Kim, Hee-Sung Park, Yeon-Soo Seo, and Byong-Seok Choi
FEBS Letters, June 2020, 594(11):1726-1737.
The interaction between ubiquitin and yeast polymerase η C terminus does not require the UBZ domain
DOI : 10.1002/1873-3468.13783
2019
1. Ina Yoon, Miso Nam, Hoi Kyoung Kim, Hee-Sun Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, SeongMin Cho, YounHa Kim, JiHye Lee, Won Suk Yang, Hee Chan Yoo, KiBum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, Geum-Sook Hwang, Kwang Yeon Hwang, Jung Min Han, Jong Hyun Kim, and SungHoon Kim
Science, 28 Nov 2019, 367(6474):205-210.
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1
2. Kyung Jin Lee, Deokhee Kang, and Hee-Sung Park
Molecules and Cells. 2019 May 31; 42(5):386-396.
Site-Specific Labeling of Proteins Using Unnatural Amino Acids.
DOI: 10.14348/molcells.2019.0078
2018
1. Donghyeok Gang, Do Wook Kim, and Hee-Sung Park
Genes 2018, 9:557.
Cyclic Peptides: Promising Scaffolds for Biopharmaceuticals.
DOI: 10.3390/genes9110557
2. Mahesh B. Halle, Kyung Jin Lee, Tesla Yudhistira, Jae Hyuck Choi, Hee-Sung Park, and David G. Churchill
Chem. Asian J. 2018, 13: 3895-3902.
A Hemicyanine-Embedded Diphenylselenide-Containing Probe “HemiSe” in which SePh2 Stays Reduced for Selective Detection of Superoxide in Living Cells.
DOI: 10.1002/asia.201801339
3. Mahesh B. Halle, Tesla Yudhistira, Kyung Jin Lee, Jae Hyuck Choi, Youngsam Kim, Hee-Sung Park, and David G. Churchill
ACS Omega 2018, 3: 13474-13483.
Overriding Phthalate Decomposition When Exploring Mycophenolic Acid Intermediates as Selenium-Based ROS Biological Probes.
DOI: 10.1021/acsomega.8b01571
4. Hyunhee Kim, Hyelim Jo, Hogyu David Seo, Hee-Sung Park, and Daeyoup Lee
Biochem. Biophys. Res. Commun. 2018 Sep 10; 503(3):1200-1206.
Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site.
DOI: 10.1016/j.bbrc.2018.07.025
5. Samira Husen Alamudi, Dongdong Su, Kyung Jin Lee, Jung Yeol Lee, José Luis Belmonte-Vázquez, Hee-Sung Park, Eduardo Peña-Cabrera and Young-Tae Chang
Chem. Sci., 2018, 9, 2376.
A palette of background-free tame fluorescent probes for intracellular multi-color labelling in live cells.
DOI: 10.1039/C7SC04716A
6. Jihye Ahn, Jin Gyeong Lee, Chuevin Chin, Suna In, Aerin Yang, Hee-Sung Park, Jaehoon Kim and Jeong Hyeon Park
Exp. Mol. Med. (2018) 50:1-12.
MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression.
DOI: 10.1038/s12276-018-0160-8
2017
1. Aerin Yang, Kyukwang Cho, and Hee-Sung Park
RNA Biol. 15(4-5):427-440.
Chemical biology approaches for studying posttranslational modifications
DOI: 10.1080/15476286.2017.1360468
2. Sandip V. Mulay, Youngsam Kim, Kyung Jin Lee, Tesla Yudhistira, Hee-Sung Park, and David G. Churchill
New J. Chem., 2017, 41, 11934-11940.
A fluorogenic and red-shifted diphenyl phosphinate-based probe for selective peroxynitrite detection as demonstrated in fixed cells
DOI: 10.1039/C7NJ02530K
3. Siyeong Yang, Hongki Kim, Kyung Jin Lee, Seul Gee Hwang, Eun-Kyung Lim, Juyeon Jung, Tae Jae Lee, Hee-Sung Park, Taejoon Kang and Bongsoo Kim
Nanoscale, 2017, 9, 17387-17395.
Attomolar detection of extracellular microRNAs released from living prostate cancer cells by a plasmonic nanowire interstice sensor
DOI: 10.1039/C7NR04386D
4. Tesla Yudhistira, Sandip V. Mulay, Kyung Jin Lee, Youngsam Kim, Hee-Sung Park and David G. Churchill
Chem. Asian J. 2017, 12, 1927 – 1934
Thiomaleimide Functionalization for Selective Biological Fluorescence Detection of Peroxynitrite as Tested in HeLa and RAW 264.7 Cells
DOI: 10.1002/asia.201700527
5. Songmi Han, Aerin Yang, Soonjang Lee, Han-Woong Lee, Chan Bae Park, and Hee-Sung Park
Nat. Comm. 2017 Feb 21;8:14568.
Expanding the genetic code of Mus musculus
DOI: 10.1038/ncomms14568
6. Sang-Woo Kim, Kyung Jin Lee, Sinil Kim, Jihyo Kim, Kyukwang Cho, Hyeon-Su Ro, Hee-Sung Park
Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3030-3037.
Genetic incorporation of Nε-acetyllysine reveals a novel acetylation-sumoylation switch in yeast
DOI: 10.1016/j.bbagen.2017.02.002
2016
1. Steven Z. Josefowicz, Miho Shimada, Anja Armache, Charles H. Li, Rand M. Miller, Shu Lin, Aerin Yang, Brian D. Dill, Henrik Molina, Hee-Sung Park, Benjamin A. Garcia, Jack Taunton, Robert G. Roeder, and C. David Allis
Mol Cell. 2016 Oct 20;64(2):347-361.
Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription
DOI: 10.1016/j.molcel.2016.09.026
2. Aerin Yang, Sura Ha, Jihye Ahn, Rira Kim, Sungyoon Kim, Younghoon Lee, Jaehoon Kim, Dieter Söll, Hee-Yoon Lee, and Hee-Sung Park
Science 2016 Nov 4;354(6312):623-626
A chemical biology route to site-specific authentic protein modifications
DOI: 10.1126/science.aah4428
3. Samira Husen Alamudi, Rudrakanta Satapathy, Jihyo Kim, Dongdong Su, Haiyan Ren, Rajkumar Das, Lingna Hu, Enrique Alvarado-Mart ́ınez, Jung Yeol Lee, Christian Hoppmann, Eduardo Pen ̃a-Cabrera, Hyung-Ho Ha, Hee-Sung Park, Lei Wang, Young-Tae Chang
Nat. Commun. Jun 20;7:11964.
Development of background-free tame fluorescent probes for intracellular live cell imaging
DOI: 10.1038/ncomms11964
4. Jieon Lee, Il-Soo Park, Ginam Park, Kyukwang Cho, Hee-Sung Park, and Dal-Hee Min
Chem. Comm. 2016, 52:12112-12115.
A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors
DOI: 10.1039/C6CC05834E
2015
1. Gil Ju Seo, Aerin Yang, Brandon Tan, Sungyoon Kim, Qiming Liang, Younho Choi, Weiming Yuan, Pinghui Feng, Hee-Sung Park, and Jae U. Jung
Cell Rep. 13(2), 440–449.
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway.
DOI: 10.1016/j.celrep.2015.09.007
2014
1. Mude Shi, Hyelim Cho, Kyung-Soo Inn, Aerin Yang, Zhen Zhao, Qiming Liang, Gijs A. Versteeg, Samad Amini-Bavil-Olyaee, Lai-Yee Wong, Barisiav Zlokovic, Hee-Sung Park, Adolfo Garcia-Sastre, Jae Jung
Nat Commun 5, 4820 (2014).
Negative reugulation of NF-κB activity by brain-specific TRIpartite Motif protein 9
DOI: 10.1038/ncomms5820
2. Yonghwang Ha, Aerin Yang, Seyoung Lee, Kibong Kim, Hyunjeong Liew, Yoo-Hun Suh, Hee-Sung Park, and David G. Churchill
Biochem. Biophys. Res. Commun. 443(3): 1085–1091
Facile "Stop Codon" Method reveals elevated Neuronal Toxicity by discrete S87p a-Synuclein oligomers
DOI: 10.1016/j.bbrc.2013.12.099
3. Yonghwang Ha, Aerin Yang, Seyoung Lee, Kibong Kim, Hyunjeong Liew, Sang Hyung Lee, Ju Eun Lee, Hong-In Lee, Yoo-Hun Suh, Hee-Sung Park, David G. Churchill
J. Neurosci. Res. 2014 Mar;92(3):359-68
Dopamine and Cu+/2+ can induce oligomerization of α-synuclein in the absence of oxygen: Two types of oligomerization mechanisms for α-synuclein and related cell toxicity studies.
DOI: 10.1002/jnr.23323
2013
1. Sangsik Lee, Seunghee Oh, Aerin Yang, Jihyo Kim, Dieter Söll, Daeyoup Lee, and Hee-Sung Park
Angew. Chem. Intl. Ed. (2013) 52(22): 5771-5775.
A Facile Strategy for Selective Phosphoserine Incorporation in Histones.
[Selected as V.I.P. and Front Cover]
DOI: 10.1002/anie.201300531
2. Jihyo Kim, Moon-Hyeong Seo, Sangsik Lee, Kyukwang Cho, Aerin Yang, Kyunghwa Woo, Hak-Sung Kim, and Hee-Sung Park
Analytical Chemistry 2013, 5(85):1468–1474
Simple and efficient strategy for site-specific dual labeling of proteins for single-molecule fluorescence resonance energy transfer analysis.
DOI: 10.1021/ac303089v
2012
1. Takuya Umehara, Jihyo Kim, Sangsik Lee, Li-Tao Guo, Dieter Söll, and Hee-Sung Park
FEBS Lett, 586(6):729-33
N-Acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo.
DOI: 10.1016/j.febslet.2012.01.029
2011
1. Moon-Hyeong Seo, Tae-Sun Lee, Eunkyung Kim, Young Lag Cho, Hee-Sung Park, Tae-Young Yoon, and Hak-Sung Kim
Anal Chem 83(23):8849-54
Efficient Single-Molecule Fluorescence Resonance Energy Transfer Analysis by Site-Specific Dual-Labeling of Protein Using an Unnatural Amino Acid.
DOI: 10.1021/ac202096t
2. Hee-Sung Park, Michael J. Hohn, Takuya Umehara, Li-Tao Guo, Edith M. Osborne, Jack Benner, Christopher J. Noren, Jesse Rinehart, Dieter Söll
Science, 333(6046): 1151-1154
Expanding the genetic code of Escherichia coli with phosphoserine.
DOI: 10.1126/science.1207203
3. Moon-Hyeong Seo, Jieun Han, Zongwen Jin, Dong-Won Lee, Hee-Sung Park, and Hak-Sung Kim
Anal. Chem. 2011, 83, 8, 2841–2845
Controlled and Oriented Immobilization of Protein by Site-Specific Incorporation of Unnatural Amino Acid
DOI: 10.1021/ac103334b
2007
1. Satwik Kamtekar, Michael J. Hohn, Hee-Sung Park, Michael Schnitzbauer, Anselm Sauerwald, Dieter Söll, and Thomas A. Steitz.
Proc. Natl. Acad. Sci. USA 104(8), 2620-2625.
Toward understanding phosphoseryl-tRNA^Cys formation: The crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
DOI: 10.1073/pnas.0611504104
2006
1. Michael Hohn, Hee-Sung Park, Patrick O’Donoghue, Michael Schnitzbauer and Dieter Söll.
Proc. Natl. Acad. Sci. USA 103(48): 18095-18100.
Emergence of the universal genetic code imprinted in an RNA record.
DOI: https://doi.org/10.1073/pnas.0608762103
2. Hee-Sung Park, Sung-Hun Nam, Jin Kak Lee, Chang No Yoon, Bengt Mannervik, Stephen J. Benkovic, and Hak-Sung Kim.
Science 311(5760): 535-538.
Design and evolution of new catalytic activity with an existing protein scaffol
DOI: 10.1126/science.1118953
2005
1. Sung-Hun Nam, Hee-Sung Park, and Hak-Sung Kim.
Chem. Rec. 5(5): 298-307.
Evolutionary relationship and application of a superfamily of cyclic amidohydrolase enzyme
DOI: 10.1002/tcr.20057
2004
1. Young-Hoon Cheon, Hee-Sung Park, Jin-Hyun Kim and Hak-Sung Kim.
Biochemistry 43(23), 7413-7420.
Manipulation of the active site loops of D-hydantoinase, a (β/α)8-barrel protein, for modulation of the substrate specificity.
DOI: 10.1021/bi036330o
2. Hee-Sung Park, Ki-Hoon Oh, and Hak-Sung Kim.
Methods Enzymol. 388: 187-195.
Improving the functional expression of N-carbamoylase by directed evolution using the green fluorescent protein fusion reporter syste
DOI: 10.1016/S0076-6879(04)88017-0
2001
1. Hee-Sung Park and Hak-Sung Kim.
J. Bacteriol. 183(17): 5074-5081.
Genetic and structural organization of the aminophenol catabolic operon and its implication for evolutionary process.
DOI: 10.1128/JB.183.17.5074-5081.2001
2000
1. Hee-Sung Park and Hak-Sung Kim.
J. Bacteriol. 182, 573-580.
Identification and characterization of NB catabolic plasmids of Pseudomonas putida HS12
DOI: 10.1128/jb.182.3.573-580.2000
1999
1. Jang-Young Lee, Hee-Sung Park, and Hak-Sung Kim.
J. Bacteriol. 181(9): 2953-2957.
Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid
2. Hee-Sung Park, Sung-Jin Lim, Yong Keun Chang, Andrew G. Livingston, and Hak-Sung Kim.
Appl. Environ. Microbiol. 65(3): 1083-1091.
Degradation of chloronitrobenzenes by a coculture of Pseudomonas putida and Rhodococcus sp.
1998
1. Hee-Sung Park, Jang-Young Lee, and Hak-Sung Kim.
Biotechnol. Bioeng. 58(2-3): 339-343.
Production of L-dopa (3,4-dihydroxyphenyl-L-alanine) from benzene by using a hybrid pathway.
DOI: 10.1002/(sici)1097-0290(19980420)58:2/3<339::aid-bit36>3.0.co;2-4