Molecular Synthetic
Biology Laboratory

분자합성생물학 및 단백질화학 연구실

Lab Experiment
 

주요 발표 논문

Major Publications

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Site-specific Protein Modification

Science, 354(6312):623-626. (2016)

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Phosphoserine Incorporation

Science, 333(6046): 1151-1154 (2011)
Angew. Chem. Int. Ed. 52(22): 5771-5775. (2013)

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Nε-Acetyl-L-Lysine Incorporation

Nat. Comm. 8:14568. (2017)
FEBS Lett, 586(6):729-33. (2012)

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Protein Labeling & Drug Screening

Anal. Chem. 5(85):1468–1474. (2013)
Chem. Comm. 52:12112-12115. (2016)

 

연구 분야

Research Area

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Site-specific Protein Modification

-"Marking-Activation-Coupling" approach to attach various functional handles to protein
-Site-specific, authentic protein modification

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Genetic Incorporation of
Unnatural Amino Acids into Proteins

- Development of new method for incorporation of unnatural amino acid into proteins
- Design and engineering of new translation machinery for genetic code expansion

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Phosphoserine Incorporation

Application of synthetic biology techniques to basic cell biology and applied medical science
- Detailed mapping of protein kinase signaling network
- Anti-cancer drug design based on activated target protein-ligand structure/modeling
- High-throughput screening of kinase inhibitors for cancer therapy

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Protein Engineering and Directed Evolution

- Development of new strategy for the redesign of proteins with novel function
- Rational design of proteins based on structure analysis
- Molecular evolution of proteins for enhanced properties

 

연락하기

대전광역시 유성구 대학로 291 (구성동)
​한국과학기술원 기초과학동 (E6-6) 519호

82) 042-350-2853

Microscope