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Molecular Synthetic
Biology Laboratory

분자합성생물학 및 단백질화학 연구실

Lab Experiment
Main: 환영 인사

주요 발표 논문

Major Publications

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Site-specific Protein Modification

Science, 354(6312):623-626. (2016)


Phosphoserine Incorporation

Science, 333(6046): 1151-1154 (2011)
Angew. Chem. Int. Ed. 52(22): 5771-5775. (2013)


Nε-Acetyl-L-Lysine Incorporation

Nat. Comm. 8:14568. (2017)
FEBS Lett, 586(6):729-33. (2012)


Protein Labeling & Drug Screening

Angew. Chem. Int. Ed. 62(7):e202214815. (2022)
Adv. Sci.  2302253 (2023)

Main: 저서

연구 분야

Research Area


Site-specific Protein Modification

-"Marking-Activation-Coupling" approach to attach various functional handles to protein
-Site-specific, authentic protein modification


Genetic Incorporation of
Unnatural Amino Acids into Proteins

- Development of new method for incorporation of unnatural amino acid into proteins
- Design and engineering of new translation machinery for genetic code expansion


Phosphoserine Incorporation

Application of synthetic biology techniques to basic cell biology and applied medical science
- Detailed mapping of protein kinase signaling network
- Anti-cancer drug design based on activated target protein-ligand structure/modeling
- High-throughput screening of kinase inhibitors for cancer therapy


Protein Engineering and Directed Evolution

- Development of new strategy for the redesign of proteins with novel function
- Rational design of proteins based on structure analysis
- Molecular evolution of proteins for enhanced properties

Main: 연구


대전광역시 유성구 대학로 291 (구성동)
​한국과학기술원 기초과학동 (E6-6) 519호

82) 042-350-2853

Main: 연락처
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