주요 발표 논문

Major Publications

Site-specific Protein Modification

Science, 354(6312):623-626. (2016)

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  1. Prasad M. Sonawane, Tesla Yudhistira, Mahesh B. Halle, Arkaprava Roychaudhury, Yunsu Kim, Sachin S. Surwase, Vikas K. Bhosale, Juhyeon Kim, Hee-Sung Park, Yeu-chun Kim, Cheol-Hee Kim, and David G. Churchill
    Dyes and Pigments. July 2021; 191:109371.
    A water-soluble boronate masked benzoindocyanin fluorescent probe for the detection of endogenous mitochondrial peroxynitrite in live cells and zebrafish as inflammation models.
    DOI: 10.1016/j.dyepig.2021.109371


  1. Donghyeok Gang, and Hee-Sung Park
    ChemBioChem, 22(3):460-468.
    Noncanonical Amino Acids in Synthetic Biosafety and Post-translational Modification Studies
    DOI: 10.1002/cbic.202000437


  1. Kyung Jin Lee, Deokhee Kang, and Hee-Sung Park
    Molecules and Cells. 2019 May 31; 42(5):386-396.
    Site-Specific Labeling of Proteins Using Unnatural Amino Acids.
    DOI: 10.14348/molcells.2019.0078


  1. Donghyeok Gang, Do Wook Kim, and Hee-Sung Park 
    Genes 2018, 9:557.
    Cyclic Peptides: Promising Scaffolds for Biopharmaceuticals.
    DOI: 10.3390/genes9110557

  2. Mahesh B. Halle, Kyung Jin Lee, Tesla Yudhistira, Jae Hyuck Choi, Hee-Sung Park, and David G. Churchill
    Chem. Asian J. 2018, 13: 3895-3902. 
    A Hemicyanine-Embedded Diphenylselenide-Containing Probe “HemiSe” in which SePh2 Stays Reduced for Selective Detection of Superoxide in Living Cells.
    DOI: 10.1002/asia.201801339

  3. Mahesh B. Halle, Tesla Yudhistira, Kyung Jin Lee, Jae Hyuck Choi, Youngsam Kim, Hee-Sung Park, and David G. Churchill
    ACS Omega 2018, 3: 13474-13483.
    Overriding Phthalate Decomposition When Exploring Mycophenolic Acid Intermediates as Selenium-Based ROS Biological Probes.
    DOI: 10.1021/acsomega.8b01571

  4. Hyunhee Kim, Hyelim Jo, Hogyu David Seo, Hee-Sung Park, and Daeyoup Lee
    Biochem. Biophys. Res. Commun. 2018 Sep 10; 503(3):1200-1206. 
    Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site.
    DOI: 10.1016/j.bbrc.2018.07.025

  5. Samira Husen Alamudi, Dongdong Su, Kyung Jin Lee, Jung Yeol Lee, José Luis Belmonte-Vázquez, Hee-Sung Park, Eduardo Peña-Cabrera and Young-Tae Chang
    Chem. Sci., 2018, 9, 2376. 
    A palette of background-free tame fluorescent probes for intracellular multi-color labelling in live cells.
    DOI: 10.1039/C7SC04716A

  6. Jihye Ahn, Jin Gyeong Lee, Chuevin Chin, Suna In, Aerin Yang, Hee-Sung Park, Jaehoon Kim and Jeong Hyeon Park
    Exp. Mol. Med. (2018) 50:1-12.
    MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression.
    DOI: 10.1038/s12276-018-0160-8


  1. Aerin Yang, Kyukwang Cho, and Hee-Sung Park 
    RNA Biol. 15(4-5):427-440.
    Chemical biology approaches for studying posttranslational modifications
    DOI: 10.1080/15476286.2017.1360468

  2. Sandip V. Mulay, Youngsam Kim, Kyung Jin Lee, Tesla Yudhistira, Hee-Sung Park, and David G. Churchill
    New J. Chem., 2017, 41, 11934-11940.
    A fluorogenic and red-shifted diphenyl phosphinate-based probe for selective peroxynitrite detection as demonstrated in fixed cells
    DOI: 10.1039/C7NJ02530K

  3. Siyeong Yang, Hongki Kim, Kyung Jin Lee, Seul Gee Hwang, Eun-Kyung Lim, Juyeon Jung, Tae Jae Lee, Hee-Sung Park, Taejoon Kang and Bongsoo Kim
    Nanoscale, 2017, 9, 17387-17395.
    Attomolar detection of extracellular microRNAs released from living prostate cancer cells by a plasmonic nanowire interstice sensor
    DOI: 10.1039/C7NR04386D

  4. Tesla Yudhistira, Sandip V. Mulay, Kyung Jin Lee, Youngsam Kim, Hee-Sung Park and David G. Churchill
    Chem. Asian J. 2017, 12, 1927 – 1934
    Thiomaleimide Functionalization for Selective Biological Fluorescence Detection of Peroxynitrite as Tested in HeLa and RAW 264.7 Cells
    DOI: 10.1002/asia.201700527

  5. Songmi Han, Aerin Yang, Soonjang Lee, Han-Woong Lee, Chan Bae Park, and Hee-Sung Park 
    Nat. Comm. 2017 Feb 21;8:14568.
    Expanding the genetic code of Mus musculus
    DOI: 10.1038/ncomms14568

  6. Sang-Woo Kim, Kyung Jin Lee, Sinil Kim, Jihyo Kim, Kyukwang Cho, Hyeon-Su Ro, Hee-Sung Park
    Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3030-3037.
    Genetic incorporation of Nε-acetyllysine reveals a novel acetylation-sumoylation switch in yeast
    DOI: 10.1016/j.bbagen.2017.02.002


  1. Steven Z. Josefowicz, Miho Shimada, Anja Armache, Charles H. Li, Rand M. Miller, Shu Lin, Aerin Yang, Brian D. Dill, Henrik Molina, Hee-Sung Park, Benjamin A. Garcia, Jack Taunton, Robert G. Roeder, and C. David Allis
    Mol Cell. 2016 Oct 20;64(2):347-361.
    Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription
    DOI: 10.1016/j.molcel.2016.09.026

  2. Aerin Yang, Sura Ha, Jihye Ahn, Rira Kim, Sungyoon Kim, Younghoon Lee, Jaehoon Kim, Dieter Söll, Hee-Yoon Lee, and Hee-Sung Park 
    Science 2016 Nov 4;354(6312):623-626
    A chemical biology route to site-specific authentic protein modifications
    DOI: 10.1126/science.aah4428

  3. Samira Husen Alamudi, Rudrakanta Satapathy, Jihyo Kim, Dongdong Su, Haiyan Ren, Rajkumar Das, Lingna Hu, Enrique Alvarado-Mart ́ınez, Jung Yeol Lee, Christian Hoppmann, Eduardo Pen ̃a-Cabrera, Hyung-Ho Ha, Hee-Sung Park, Lei Wang, Young-Tae Chang
    Nat. Commun. Jun 20;7:11964.
    Development of background-free tame fluorescent probes for intracellular live cell imaging
    DOI: 10.1038/ncomms11964

  4. Jieon Lee, Il-Soo Park, Ginam Park, Kyukwang Cho,  Hee-Sung Park, and Dal-Hee Min
    Chem. Comm. 2016, 52:12112-12115.
    A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors
    DOI: 10.1039/C6CC05834E


  1. Gil Ju Seo, Aerin Yang, Brandon Tan, Sungyoon Kim, Qiming Liang, Younho Choi, Weiming Yuan, Pinghui Feng, Hee-Sung Park, and Jae U. Jung 
    Cell Rep. 13(2), 440–449.
    Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway.
    DOI: 10.1016/j.celrep.2015.09.007


  1. Mude Shi, Hyelim Cho, Kyung-Soo Inn, Aerin Yang, Zhen Zhao, Qiming Liang, Gijs A. Versteeg, Samad Amini-Bavil-Olyaee, Lai-Yee Wong, Barisiav Zlokovic, Hee-Sung Park, Adolfo Garcia-Sastre, Jae Jung
    Nat Commun 5, 4820 (2014).
    Negative reugulation of NF-κB activity by brain-specific TRIpartite Motif protein 9
    DOI: 10.1038/ncomms5820

  2. Yonghwang Ha, Aerin Yang, Seyoung Lee, Kibong Kim, Hyunjeong Liew, Yoo-Hun Suh, Hee-Sung Park, and David G. Churchill 
    Biochem. Biophys. Res. Commun. 443(3): 1085–1091
    Facile "Stop Codon" Method reveals elevated Neuronal Toxicity by discrete S87p a-Synuclein oligomers
    DOI: 10.1016/j.bbrc.2013.12.099

  3. Yonghwang Ha, Aerin Yang, Seyoung Lee, Kibong Kim, Hyunjeong Liew, Sang Hyung Lee, Ju Eun Lee, Hong-In Lee, Yoo-Hun Suh, Hee-Sung Park, David G. Churchill 
    J. Neurosci. Res. 2014 Mar;92(3):359-68
    Dopamine and Cu+/2+ can induce oligomerization of α-synuclein in the absence of oxygen: Two types of oligomerization mechanisms for α-synuclein and related cell toxicity studies.
    DOI: 10.1002/jnr.23323


  1. Sangsik Lee, Seunghee Oh, Aerin Yang, Jihyo Kim, Dieter Söll, Daeyoup Lee, and Hee-Sung Park 
    Angew. Chem. Int. Ed. (2013) 52(22): 5771-5775.
    A Facile Strategy for Selective Phosphoserine Incorporation in Histones. 
    [Selected as V.I.P. and Front Cover]
    DOI: 10.1002/anie.201300531

  2. Jihyo Kim, Moon-Hyeong Seo, Sangsik LeeKyukwang Cho, Aerin Yang, Kyunghwa Woo, Hak-Sung Kim, and Hee-Sung Park 
    Analytical Chemistry 2013, 5(85):1468–1474
    Simple and efficient strategy for site-specific dual labeling of proteins for single-molecule fluorescence resonance energy transfer analysis. 
    DOI: 10.1021/ac303089v


  1. Takuya Umehara, Jihyo Kim, Sangsik Lee, Li-Tao Guo, Dieter Söll, and Hee-Sung Park 
    FEBS Lett, 586(6):729-33
    N-Acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo. 
    DOI: 10.1016/j.febslet.2012.01.029


  1. Moon-Hyeong Seo, Tae-Sun Lee, Eunkyung Kim, Young Lag Cho, Hee-Sung Park, Tae-Young Yoon, and Hak-Sung Kim
    Anal Chem​ 83(23):8849-54
    Efficient Single-Molecule Fluorescence Resonance Energy Transfer Analysis by Site-Specific Dual-Labeling of Protein Using an Unnatural Amino Acid. 
    DOI: 10.1021/ac202096t

  2. Hee-Sung Park, Michael J. Hohn, Takuya Umehara, Li-Tao Guo, Edith M. Osborne, Jack Benner, Christopher J. Noren, Jesse Rinehart, Dieter Söll
    Science, 333(6046): 1151-1154 
    Expanding the genetic code of Escherichia coli with phosphoserine. 
    DOI: 10.1126/science.1207203

  3. Moon-Hyeong Seo, Jieun Han, Zongwen Jin, Dong-Won Lee, Hee-Sung Park, and Hak-Sung Kim 
    Anal. Chem. 2011, 83, 8, 2841–2845
    Controlled and Oriented Immobilization of Protein by Site-Specific Incorporation of Unnatural Amino Acid
    DOI: 10.1021/ac103334b


  1. Satwik Kamtekar, Michael J. Hohn, Hee-Sung Park, Michael Schnitzbauer, Anselm Sauerwald, Dieter Söll, and Thomas A. Steitz.
    Proc. Natl. Acad. Sci. USA 104(8), 2620-2625.
    Toward understanding phosphoseryl-tRNA^Cys formation: The crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
    DOI: 10.1073/pnas.0611504104


  1. Michael Hohn, Hee-Sung Park, Patrick O’Donoghue, Michael Schnitzbauer and Dieter Söll.
    Proc. Natl. Acad. Sci. USA 103(48): 18095-18100.
    Emergence of the universal genetic code imprinted in an RNA record.
    DOI: https://doi.org/10.1073/pnas.0608762103

  2. Hee-Sung Park, Sung-Hun Nam, Jin Kak Lee, Chang No Yoon, Bengt Mannervik, Stephen J. Benkovic, and Hak-Sung Kim.
    Science 311(5760): 535-538.
    Design and evolution of new catalytic activity with an existing protein scaffol
    DOI: 10.1126/science.1118953


  1. Sung-Hun Nam, Hee-Sung Park, and Hak-Sung Kim.
    Chem. Rec. 5(5): 298-307.
    Evolutionary relationship and application of a superfamily of cyclic amidohydrolase enzyme
    DOI: 10.1002/tcr.20057


  1. Young-Hoon Cheon, Hee-Sung Park, Jin-Hyun Kim and Hak-Sung Kim.
    Biochemistry 43(23), 7413-7420.
    Manipulation of the active site loops of D-hydantoinase, a (β/α)8-barrel protein, for modulation of the substrate specificity.
    DOI: 10.1021/bi036330o

  2. Hee-Sung Park, Ki-Hoon Oh, and Hak-Sung Kim.
    Methods Enzymol. 388: 187-195.
    Improving the functional expression of N-carbamoylase by directed evolution using the green fluorescent protein fusion reporter syste
    DOI: 10.1016/S0076-6879(04)88017-0


  1. Hee-Sung Park and Hak-Sung Kim.
    J. Bacteriol. 183(17): 5074-5081.
    Genetic and structural organization of the aminophenol catabolic operon and its implication for evolutionary process.
    DOI: 10.1128/JB.183.17.5074-5081.2001


  1. Hee-Sung Park and Hak-Sung Kim.
    J. Bacteriol. 182, 573-580.
    Identification and characterization of NB catabolic plasmids of Pseudomonas putida HS12
    DOI: 10.1128/jb.182.3.573-580.2000


  1. Jang-Young Lee, Hee-Sung Park, and Hak-Sung Kim. 
    J. Bacteriol. 181(9): 2953-2957.
    Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid

  2. Hee-Sung Park, Sung-Jin Lim, Yong Keun Chang, Andrew G. Livingston, and Hak-Sung Kim.
    Appl. Environ. Microbiol. 65(3): 1083-1091.
    Degradation of chloronitrobenzenes by a coculture of Pseudomonas putida and Rhodococcus sp.


  1. Hee-Sung Park, Jang-Young Lee, and Hak-Sung Kim. 
    Biotechnol. Bioeng. 58(2-3): 339-343.
    Production of L-dopa (3,4-dihydroxyphenyl-L-alanine) from benzene by using a hybrid pathway.
    DOI: 10.1002/(sici)1097-0290(19980420)58:2/3<339::aid-bit36>3.0.co;2-4